Impurities

	Semaglutide	Liraglutide	Tirzepatide	Teduglutide	Calcitonin	Cetrorelix	Vasopressin	Desmopressin	Leuprolide	Octreotide	Icatibant	Teriparatide	Linaclotide	Plecanatide	Glucagon
Impurities
Isomers (D&L)	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
Deletion (missing amino acids)	✓	✓	✓	✓	✓	✓		✓	✓	✓	✓	✓	✓	✓	✓
Endo (additional amino acids)	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
Truncation (shortened peptide)	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
Oxidation (Trp, MeT, etc.)	✓	✓	✓	✓								✓			✓
Cyclic (disulfide bridges, cyclic his)					✓					✓	✓		✓	✓
Dimers (parallel and antiparallel, head to tail, etc)	head to tail	head to tail	head to tail				parallel/Antiparallel
C-terminal acid/amine					C-terminal acid
Salt (acetate, trifluoroacetate, sodium, phosphate)	Sodium, TFA	TFA		TFA, sodium		Acetate			Acetate	Acetate	Acetate				HCl
Free base	✓	✓	✓		✓							✓